Its continued development and improvement assure that they may continue to use the analysis tool with which they are familiar for present‐day pharmaceutical development. The NONMEM software was originally developed by Lewis Sheiner and Stuart Beal and the NONMEM Project Group at the University of California and has been used for more than 30 years for population analysis by many pharmaceutical companies and the PK/PD modeling community. The development and application of PK/PD models by pharmaceutical scientists using the appropriate statistical methodology can provide a basis for determining optimal dosing strategies for their products and increases their understanding of drug mechanisms and interactions. 1 It solves pharmaceutical statistical problems in which within‐subject and between‐subjects variability is taken into account when fitting a pharmacokinetic and/or pharmacodynamic (PK/PD) model to data. NONMEM is a computer program that is implemented in Fortran90/95. NONMEM stands for NONlinear Mixed Effects Modeling.
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